期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 23, 期 10, 页码 1300-1306出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2013.01.010
关键词
Adolescents; Brain-derived neurotrophic factor; Depression; Maltreatment; Serotonin transporter; Sexual abuse
资金
- Swedish Research Council (VR)
- Swedish Brain Foundation
- Swedish Labour Market Insurance Company (AFA)
- Swedish Alcohol Monopoly Research Council (SRA)
- Swedish Council for Working Life and Social Research (FAS)
- Uppsala and Orebro Regional Research Council
- Fredrik and Ingrid Thurings Foundation
- County Council of Vastmanland
- Konig-Soderstromska Foundation
- Swedish Psychiatric Foundation
- Svenska Spel Research Foundation
Both the serotonin transporter linked promoter region (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms have been shown to interact with unfavourable environment in relation to depression symptoms and to depression diagnosis. Several attempts have been made to study a three-way interaction effect of these factors on depression, however with contradictory results. We aimed to test the hypothesis of a three-way interaction effect and to attempt at replication in an independent population-based sample. Family maltreatment, sexual abuse and depression were self-reported by an adolescent population-based cohort (N=1393) from the county of Vastmanland, Sweden. DNA was isolated from saliva, and used for genotyping of the 5-HTTLPR and BDNF Val66Met polymorphisms. Neither 5-HTTLPR or BDNF genotypes separately, nor in interaction with each other had any relation to depression, however in an environment adjusted model a two-way interaction and a three-way interaction effect was found. Both 5-HTTLPR and BDNF Val66Met interacted with unfavourable environment in relation to depressive symptoms (Adj R-2=0.19). Depressive symptoms and depression were more common among carriers of either the ss/sl+Val/Val or the ll+Met genotypes in the presence of early-life adversities. This three-way effect was more pronounced among girls. The current study, with a virtually similar set-up compared to previous studies, can partially confirm previous findings and their generalizability. The study also shows the importance of genetic plasticity in individuals with different environmental exposure, for different phenotypic expression. (C) 2013 Elsevier B.V. and ECNP. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据