期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 21, 期 11, 页码 796-809出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2011.06.001
关键词
Posttraumatic stress disorder; Animal model; Hydrocortisone; Secondary prevention; Dendritic arborization; Brain-derived neurotrophic factor (BDNF); Postsynaptic density-95 (PSD-95)
资金
- National Institute for Psychobiology in Israel
- Charles E. Smith Family
- Israel Academy of Science and Humanities [416/09]
- Ministry of Health [3-0000-6086]
High-dose corticosteroids have been reported to reduce symptoms of acute stress and post-traumatic stress in polytrauma patients and in animal studies. The underlying mechanism of action remains largely unclear. These issues were addressed in parallel in the clinical and preclinical studies below. In this preliminary study, 25 patients with acute stress symptoms were administered a single intravenous bolus of high-dose hydrocortisone (100-140 mg) or placebo within 6 h of a traumatic event in a prospective, randomized, double-blind, placebo-controlled pilot study. Early single high-dose hydrocortisone intervention attenuated the core symptoms of both the acute stress and of subsequent PTSD in patients. High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma. In parallel, a comparative study of morphological arborization in dentate gyrus and its modulating molecules was performed in stress-exposed animals treated with high-dose hydrocortisone. Steroid-treated stressed animals displayed significantly increased dendritic growth and spine density, with increased levels of brain-derived neurotrophic factor (BDNF) and obtunded postsynaptic density-95 (PSD-95) levels. The animal study provided insights into the potential mechanism of this intervention, as it identified relevant morphological and biochemical associations to the clinical observations. Thus, evidence from clinical and animal studies suggests that there is a window of opportunity in the early aftermath of trauma to help those who are vulnerable to the development of chronic PTSD. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据