期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 21, 期 1, 页码 11-22出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2010.06.007
关键词
CB1 cannabinoid receptor; Depression; Stress; Gene expression
资金
- EC [LSHM-CT-2004-503474]
- Spanish Ministerio de Ciencia e Innovacion [SAF2007-64062]
- Instituto de Salud Carlos III [RD06/001/001]
- Catalan government (ICREA) [SGR2009-00131]
- Spanish Ministry of Education and Science [BES-2005-8265]
- Sanofi-Aventis
- Dr Esteve laboratories
- Ferrer laboratories
Recent hypotheses to explain the neurobiology of depression underline the role played by stress in mood disorders. The endocannabinoid system is one of the major physiological substrates involved in emotional responses and stress. Thus, mice lacking CB, receptor exhibit a depressive-like phenotype and an increased vulnerability to deleterious effects of stress. In order to identify possible molecular pathways contributing to this phenotype, we have examined the gene expression profile of mutants at basal conditions and after the exposure to repeated stress. Several genes coding for neurotransmitter receptors, neurotrophic factors, neuropeptides and hormones receptors were differentially expressed in CB, knockout mice. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.
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