期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 20, 期 6, 页码 421-425出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2010.02.011
关键词
Dopamine; D2 receptor; Prepulse inhibition; Schizophrenia; Sumanirole
资金
- National Association for Research on Schizophrenia and Depression
- Tourette Syndrome Association [MH01436, MH68366]
- Allergan Pharmaceuticals
- Sanofi/Aventis
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH068366, K02MH001436] Funding Source: NIH RePORTER
Dopamine agonists reduce prepulse inhibition (PPI) of startle in rats. While it is used to predict antipsychotic efficacy, the specific receptor subtypes mediating this effect of dopamine agonists remain unclear. We characterized the effects of sumanirole, a highly selective 02 agonist, on PPI in rats. Sumanirole decreased PPI at 60-120 ms prepulse intervals, and increased PPI at 10-20 ms intervals. PPI deficits were antagonized by low doses of the preferential D2 antagonist L741626, supporting a D2 mechanism of action. Sumanirole is a valuable tool for parsing the role of dopamine receptor subtypes in the regulation of PPI. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.
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