期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 19, 期 11, 页码 791-795出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2009.06.002
关键词
Lithium prophylaxis; Bipolar disorder; Cognitive functions; Bipolar offspring; Wisconsin Card Sorting Test
资金
- Polish Committee of Scientific Research (KBN) [2PO5B 01226, 2PO5B 12326, 2PO5B 04430]
We assessed performance on the Wisconsin Card Sorting Test (WCST), measuring executive functions, in 30 patients showing different prophylactic effect of lithium (excellent lithium responders-ER, partial responders-PR and non-responders-NR), and in fifty persons of their offspring (12 of ER, 26 of PR, and 12 of NR). Age- and gender head-to-head matched population consisted of 30 subjects for lithium group and 50 subjects for the offspring of lithium patients. In lithium patients, NR had significantly worse results compared to the remaining groups and to control subjects on perseverative errors (WCST-P) and conceptual responses (WCST-%conc). No differences were observed in the offspring of patients with different effect of lithium, however, they showed an impairment on WCST-P and WCST-%conc compared to matched healthy controls. Therefore, the favorable effect of lithium prophylaxis may be associated with a preservation of executive cognitive functions and the offspring of bipolar patients shows an impairment of such functions. (C) 2009 Elsevier B.V. and ECNR All rights reserved.
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