期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 33, 页码 10496-10499出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b06659
关键词
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资金
- National Natural Science Foundation of China [21472188, 21125208]
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2014167]
A concise deracemization of racemic secondary and tertiary amines with a tetrahydroisoquinoline core has been successfully realized by orchestrating a redox process consisted of N-bromosuccinimide oxidation and iridum-catalyzed asymmetric hydrogenation. This compatible redox combination enables one-pot, single-operation deracemization to generate chiral 1-substituted 1,2,3,4-tetrahydroisoquinolines with up to 98% ee in 93% yield, offering a simple and scalable synthetic technique for chiral amines directly from racemic starting materials.
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