期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 18, 页码 5887-5890出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b02809
关键词
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资金
- CPRIT
- Welch Foundation [F-1781]
Herein we report a highly meta-selective C-H arylation using simple tertiary amines as the directing group. This method takes advantage of Pd/norbornene catalysis, offering a distinct strategy to control the site selectivity. The reaction was promoted by commercially available AsPh3 as the ligand and a unique acetate cocktail. Aryl iodides with an ortho electron-withdrawing group were employed as the coupling partner. A wide range of functional groups, including some heteroarenes, are tolerated under the reaction conditions. In addition, the amine directing group can be easily installed and transformed to other common versatile functional groups. We expect this C-H functionalization mode to have broad implications for developing other meta-selective transformations beyond this work.
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