期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 18, 期 3, 页码 230-233出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2007.06.004
关键词
cytokines; inflammation; depression; major depressive disorder; stress; cardiovascular
资金
- NIMH NIH HHS [R10 MH56058, R10 MH056057-03] Funding Source: Medline
Recent technological advances offer an opportunity to further elucidate the complex cytokine network in Major Depressive Disorder (MDD). Twenty cytokines were simultaneously assessed in 49 individuals with MDD and 49 age and gender matched controls. Multiple pro-inflammatory and two anti-inflammatory cytokines were significantly elevated in the MDD sample, including an antidepressant naive subset. These data support a generalized chronic inflammatory state in MDD, and implicate additional cytokines and chemokines previously linked to cardiovascular disease. (c) 2007 Elsevier B.V. and ECNP. All rights reserved.
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