期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 21, 页码 6742-6745出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b03091
关键词
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资金
- NSF [GM-55382]
- Samsung Scholarship
We report a Rh-catalyzed, enantioselective silylation of arene C-H bonds directed by a (hydrido)silyl group. (Hydrido)silyl ethers that are formed in situ by hydrosilylation of benzophenone or its derivatives undergo asymmetric C-H silylation in high yield with excellent enantioselectivity in the presence of [Rh(cod)Cl](2) and a chiral bisphosphine ligand. The stereoselectivity of this process also allows enantioenriched diarylmethanols to react with site selectivity at one aryl group over the other. Enantioenriched benzoxasiloles from the silylation process undergo a range of transformations to form C-C, C-O, C-I, or C-Br bonds.
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