期刊
EUROPEAN NEUROLOGY
卷 72, 期 1-2, 页码 1-6出版社
KARGER
DOI: 10.1159/000358054
关键词
Olfactory testing; Tremor; Parkinson's disease; Essential tremor
资金
- GlaxoSmithKline
- Valeant
- Pfizer
- Teva
- Novartis
- Medtronic
- Abbot
- Desitin
- Orion
- Schwarz Pharma
- UCB
- Teva/Lundbeck
- Center for Regenerative Therapies Dresden
- Takasago
- Unilever
- Fragrance Resources
- Primavera
- Givaudan
- Burghart
- Deutsche Forschungsgemeinschaft (DFG)
- Cephalon
- GSK
- Boehringer Ingelheim
- Bayer Health Care
- UCB Schwarz Pharma
- Hoffmann-La Roche
- Britannia
- Lundbeck
- MEDA
- Merz
- Mundipharma
Background/Aims: The diagnostic value of olfactory testing for the discrimination of tremor-dominant Parkinson's disease (PD) from other tremor disorders remains enigmatic. We evaluated whether olfactory testing can accurately detect PD in tremor patients. Methods: A retrospective analysis of 299 consecutive subjects referred for the differential diagnosis of a tremor disorder was done. Olfactory testing was performed using 'Sniffin' Sticks', resulting in a composite TDI score of odor threshold (T), discrimination (D), and identification (I). Receiver operating curve (ROC) plots were used to calculate sensitivity/specificity for the detection of PD. Results: Of all subjects, 167 (55.9%) had PD and 85 (28.4%) had essential tremor (ET). The mean TDI score in PD was significantly reduced compared to those in ET and other tremor disorders with no differences between ET and other tremor disorders. ROC analysis revealed strong correlations of TDI scores with PD [ area under the curve: 0.85 (95% CI: 0.80-0.89); p < 0.001]. The highest Youden index was observed for a TDI score <25 (Youden index: 0.58). Using this cutoff score and that generated from normative data of healthy controls, the TDI score provided high sensitivity (negative predictive value) and specificity (positive predictive value) of approximately 80% for detecting PD. Conclusion: Olfactory testing is a useful, easily applied and inexpensive diagnostic test which is helpful to detect PD among tremor patients. (C) 2014 S. Karger AG, Basel
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