期刊
EUROPEAN NEUROLOGY
卷 68, 期 1, 页码 23-27出版社
KARGER
DOI: 10.1159/000337683
关键词
Corpus callosum; Magnetic resonance imaging; Monitoring; Multiple sclerosis
资金
- Biogen Idec Inc.
- [MZOVFN2005]
- [MSM 0021620849]
Aim: To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis. Methods: In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T-2 and T-1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after treatment initiation. Non-parametric and multiple regression models were built to identify the most reliable predictors of disability and of its changes over 9 years. Results: Corpus callosum atrophy during the first year of treatment was the best predictor of disability (r = -0.56) and of its increase at 9 years (r = 0.65). Corpus callosum atrophy of at least 2% predicted increase in disability with 93% sensitivity and 73% specificity (odds ratio = 35). Conclusion: Corpus callosum atrophy is a simple and accurate predictor of future disability accumulation and is feasible for routine clinical practice. Copyright (C) 2012 S. Karger AG, Basel
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