期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 5, 页码 1947-1955出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja511560b
关键词
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资金
- National Basic Research Program of China [2012CB934000, 2011CB933401]
- National Natural Science Foundation of China [11205166, 21225312, 21320102003]
- National Science Fund for Distinguished Young Scholars [11425520]
- International Science & Technology Cooperation Program of China [2013DFG32340]
- Ministry of Science Technology of China [2011YQ030134]
- German Federal Ministry of Education and Research [BMBF 0315773A]
- FDA Nanotechnology CORES Program
Under evolutionary pressure from chemotherapy, cancer cells develop resistance characteristics such as a low redox state, which eventually leads to treatment failures. An attractive option for combatting resistance is producing a high concentration of produced free radicals in situ. Here, we report the production and use of dispersible hollow carbon nanospheres (HCSs) as a novel platform for delivering the drug doxorubicine (DOX) and generating additional cellular reactive oxygen species using near-infrared laser irradiation. These irradiated HCSs catalyzed sufficiently persistent free radicals to produce a large number of heat shock factor-1 protein homotrimers, thereby suppressing the activation and function of resistance-related genes. Laser irradiation also promoted the release of DOX from lysosomal DOX@HCSs into the cytoplasm so that it could enter cell nuclei. As a result, DOX@HCSs reduced the resistance of human breast cancer cells (MCF-7/ADR) to DOX through the synergy among photothermal effects, increased generation of free radicals, and chemotherapy with the aid of laser irradiation. HCSs can provide a unique and versatile platform for combatting chemotherapy-resistant cancer cells. These findings provide new clinical strategies and insights for the treatment of resistant cancers.
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