期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 15, 页码 5193-5198出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b02052
关键词
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资金
- ERATO program from JST
- Funding Program for Next Generation World-Leading Researchers from JSPS [220GR049]
- Asahi Kasei Pharma Award in Synthetic Organic Chemistry, Japan
- Integrative Graduate Education and Research Program in Green Natural Sciences
- World Premier International Research Center (WPI) Initiative, Japan
- Grants-in-Aid for Scientific Research [15J04927] Funding Source: KAKEN
A highly para-selective aromatic C-H borylation has been accomplished. By a new iridium catalyst bearing a bulky diphosphine ligand, Xyl-MeO-BIPHEP, the C-H borylation of monosubstituted benzenes can be affected with para-selectivity up to 91%. This catalytic system is quite different from the usual iridium catalysts that cannot distinguish meta- and para-C-H bonds of monosubstituted benzene derivatives, resulting in the preferred formation of meta-products. The para-selectivity increases with increasing bulkiness of the substituent on the arene, indicating that the regioselectivity of the present reaction is primarily controlled by steric repulsion between substrate and catalyst. Caramiphen, an anticholinergic drug used in the treatment of Parkinsons disease, was converted into five derivatives via our para-selective borylation. The present [Ir(cod)OH](2)/Xyl-MeO-BIPHEP catalyst represents a unique, sterically controlled, para-selective, aromatic C-H borylation system that should find use in streamlined, predictable chemical synthesis and in the rapid discovery and optimization of pharmaceuticals and materials.
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