期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 23, 页码 7286-7289出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b04285
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资金
- NIGMS of the National Institutes of Health [GM-065255]
Mimicking noncovalent interaction based processes in nature hag been an important goal of supramolecular chemistry. Here, we report on amphiphilic polypeptides that self-assemble to form nanoscale supramolecular assemblies and are programmed to disassemble in response to a specific protein. Benzenesulfonamide and carbonic anhydrase have been chosen as the ligand and protein, respectively, to demonstrate this possibility. Slice the amphiphilic nanoassembly sequesters hydrophobic guest molecules, the protein-specific disassembly event provides a protein-sensitive molecular release as well We envision that the binding induced disassembly and guest release might open up new opportunities for the next generation of supramolecular assemblies for protein-specific delivery and diagnostics.
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