期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 1, 页码 126-133出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b10800
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资金
- Czech Science Foundation [GA13-25775S]
- Czech Ministry of Health [RVO-VFN64165/2015]
- Czech Ministry of Education [LO1214, LM2011028]
Carbon monoxide-releasing molecules (CORMs) are chemical agents used to administer CO as an endogenous, biologically active molecule. A precise spatial and temporal control over the CO release is the major requirement for their applications. Here, we report the synthesis and properties of a new generation of transition-metalfree carbon monoxide-releasing molecules based on BODIPY chromophores (COR-BDPs) activatable by visible-to-NIR (up to 730 nm) light. We demonstrate their performance for both in vitro and in vivo experimental settings, and we propose the mechanism of the CO release based on steady-state and transient spectroscopy experiments and quantum chemical calculations.
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