期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 17, 页码 5654-5657出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b02244
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资金
- NIGMS [R01 GM093213-05]
The direct conversion of aliphatic carboxylic acids to the corresponding alkyl fluorides has been achieved via visible light-promoted photoredox catalysis. This operationally simple, redox-neutral fluorination method is amenable to a wide variety of carboxylic acids. Photon-induced oxidation of carboxylates leads to the formation of carboxyl radicals, which upon rapid CO2-extrusion and F-center dot transfer from a fluorinating reagent yield the desired fluoroalkanes with high efficiency. Experimental evidence indicates that an oxidative quenching pathway is operable in this broadly applicable fluorination protocol.
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