期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 4, 页码 1408-1411出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja512306a
关键词
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资金
- UT Austin
- CPRIT
- NIGMS [R01GM109054-01]
- Welch Foundation [F 1781]
Herein we report a [5 + 2 - 1] transformation though catalytic decarbonylative coupling between isatins and alkynes, which provides a unique way to synthesize 2-quinolinone derivatives. A broad range of alkynes can be coupled efficiently with high regioselectivity. This reaction is proposed to go through C-C activation of isatins, followed by decarbonylation and alkyne insertion. Directing group (DG) plays a critical role in this transformation. Assisted by the DG, the C-C cleavage of isatins occurs at room temperature.
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