期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 20, 页码 6488-6491出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b03510
关键词
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资金
- University of North Carolina at Chapel Hill
- Petroleum Research Fund of the American Chemical Society [52447-DNI1]
- Eli Lilly New Faculty Award
The activation of carbodicarbene (CDC)-Rh(I) pincer complexes by secondary binding of metal salts is reported for the catalytic site-selective hydro-heteroarylation of dienes (up to 98% yield and >98:2 gamma:alpha). Reactions are promoted by 5 mol % of a readily available tridentate (CDC)-Rh complex in the presence of an inexpensive lithium salt. The reaction is compatible with a variety of terminal and internal dienes and tolerant of ester, alkyl halide, and boronate ester functional groups. X-ray data and mechanistic experiments provide support for the role of the metal salts on catalyst activation and shed light on the reaction mechanism. The increased efficiency (120 to 22 degrees C) made available by catalytic amounts of metal salts to catalysts containing C(0) donors is a significant aspect of the disclosed studies.
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