期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 27, 页码 8700-8703出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b05086
关键词
-
资金
- National Natural Science Foundation of China
- National Basic Research Program of China [2012CB821600]
- 111 project of the Ministry of Education of China [B06005]
- National Program for Support of Top-notch Young Professionals
- Fundamental Research Funds for the Central Universities
The asymmetric arylation of diazo compounds with aniline derivatives cooperatively catalyzed by an achiral dirhodium complex and a chiral spiro phosphoric acid is reported. The reaction provides a new method for the facile synthesis of a-diarylacetates, versatile building blocks with alpha-diaryl tertiary chiral center, in good yields (up to 95%) with high enantioselectivities (up to 97% ee). Preliminary mechanistic studies suggest that the arylation reaction proceeds via a stepwise process, in which the enantioselectivity is controlled by a chiral spiro phosphoric acid-promoted proton shift in a zwitterionic intermediate. This work represents the first asymmetric intermolecular C(sp(2))-H bond insertion reaction with arenes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据