期刊
EUROPEAN JOURNAL OF RADIOLOGY
卷 81, 期 5, 页码 821-824出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2011.02.033
关键词
Computed tomography; Colon; Rectum; Perfusion CT
资金
- National Institutes of Health Research (NIHR) [PB-PG-0909-19044] Funding Source: National Institutes of Health Research (NIHR)
- Department of Health [09/22/49, PB-PG-0909-19044, PB-PG-0110-21073] Funding Source: Medline
The aim was to determine the feasibility of vascular quantification of the bowel wall for different anatomical segments of the colorectum. Following institutional ethical approval and informed consent, 39 patients with colorectal cancer underwent perfusion CT. Blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface area product (PS) were assessed for different segments of the colorectum: ascending, transverse, descending colon, sigmoid, or rectum, that were distant from the tumor, and which were proven normal on contemporary colonoscopy, and subsequent imaging and clinical follow up. Mean (SD) for BF, BV, MTT and PS for the different anatomical colorectal segments were obtained and compared using a pooled t-test. Significance was at 5%. Assessment was not possible in 9 of 39 (23%) patients as the bowel wall was <= 5 mm precluding quantitative analysis. Forty-four segments were evaluated in the remaining 30 patients. Mean BF was higher in the proximal than distal colon: 24.0 versus 17.8 mL/min/100 g tissue; p = 0.009; BV, MTT and PS were not significantly different; BV: 3.46 versus 3.15 mL/100 g tissue, p = 0.45; MTT: 15.1 versus 18.3 s; p = 0.10; PS: 6.84 versus 8.97 mL/min/100 tissue, p = 0.13, respectively. In conclusion, assessment of bowel wall perfusion may fail in 23% of patients. The colorectum demonstrates segmental differences in perfusion. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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