期刊
EUROPEAN JOURNAL OF RADIOLOGY
卷 81, 期 11, 页码 3115-3119出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2012.06.009
关键词
Sensitivity and specificity; Diffusion magnetic resonance imaging; Bladder cancer; Recurrence; ROC curve
Objective: The aim of this retrospective study was to investigate the association between the pretreatment apparent diffusion coefficient (ADC) value and recurrence of bladder cancer after transurethral resection. Methods: Patients with superficial bladder cancer were identified. Mean ADC values of the tumors were compared between patients with and without recurrence following trans-urethral resection. A receiver-operator characteristic curve was used for determining the optimal cutoff ADC value. Univariate and multivariate analyses were used to determine the effect of ADC values and other factors. Results: With a mean follow-up period of 25 months, bladder cancer recurred in 14 of 44 patients (32%). The mean ADC value of tumors in patients with recurrence was lower than in those without recurrence (1.08 mm(2)/s vs. 1.28 x 10(-3)mm(2)/s; p = 0.003). The optimal cutoff ADC value for predicting recurrence was determined to be 1.12 x 10(-3)mm(2)/s. A modest and significant negative correlation was observed between the ADC values and tumor size (r = -0.436, p = 0.008). After adjustment for size and risk groups, an ADC value equal to or less than the optimal cutoff remained a significant predictor of recurrence (odds ratio 6.3, 95% CI 1.23-32.2, p = 0.027). Conclusion: Pretreatment ADC values may be an independent predictor of bladder cancer recurrence. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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