期刊
EUROPEAN JOURNAL OF RADIOLOGY
卷 81, 期 9, 页码 1976-1979出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2011.05.004
关键词
Hepatocellular carcinoma; Interventional radiology; Polyvinyl alcohol particle
Aim: Transcatheter arterial chemoembolization (TACE) is one of major treatment for unresectable hepatocellular carcinomas (HCC) and has been used as a neoadjuvant treatment before surgery. This study was to describe the histopathologic features of HCC after TACE with variously sized polyvinyl alcohol (PVA) particles. Materials and methods: Seventeen patients undergoing TACE with PVA followed by surgery for HCC were analyzed. The PVA particles used in TACE were categorized into two groups in respects of particle sizes: the group I, 47-90 mu m (n = 8) and the group II, >90-250 mu m (n = 9). The histopathologic features of the resected HCC were characterized with the emphasis on the number of thrombosed vessels and minimal diameter of arterioles/capillaries containing polyvinyl alcohol particles. The clinical results after TACE were also addressed. Results: Histopathologic examinations showed that the median minimal diameters of arterioles containing PVA particles were 0.035 mm in group I and 0.06 mm in group II (p = 0.0078). We observed the PVA particle in the sinusoidal spaces of non-tumourous liver in only one patient. However, no sinusoidal infarction was demonstrated in either group. Mean tumour necrosis rate was 67% vs. 61% for the group I and II, respectively. Conclusions: The smaller PVA particles can reach and occlude more distal arteriolar capillaries, but rarely leak into non-tumourous hepatic sinusoidal spaces. Slightly better tumour necrosis rate after TACE can be achieved. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.
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