4.5 Article

Dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) for differential diagnosis in head and neck cancers

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EUROPEAN JOURNAL OF RADIOLOGY
卷 81, 期 4, 页码 784-788

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ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2011.01.089

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Dynamic contrast enhancement magnetic resonance imaging (DCE-MRI); Squamous cell carcinoma; Undifferentiated carcinoma and lymphoma; Diagnosis

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Purpose: To examine the potential of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for differential diagnosis of head and neck cancer. Methods and materials: DCE-MRI was performed in 26 patients with untreated squamous cell carcinoma (SCC), 28 undifferentiated carcinoma (UD) and 8 lymphoma. DCE-MRI was analyzed with the pharmacokinetic model proposed by Tofts and Kermode to produce the three DCE parameters: k(trans), nu(e) and nu(p). Areas under the curve (AUC) at the initial 60 and 90 s (AUC60 and AUC90) were also recorded. Histogram analysis was conducted to obtain the mean, 25%, 50%, 75% and 95% percentile values and the Kruskal-Wallis test was used to compare the DCE parameters between the three groups of cancer. Results: k(trans), AUC60 and AUC90 showed significant differences (p < 0.01) between UD/SCC and UD/lymphoma, but not between SCC/lymphoma. The mean AUC90 demonstrated the highest accuracy of 78% (sensitivity of 68% and specificity of 88%) for distinguishing UD and SCC, and the 75% percentile AUC90 provided the highest accuracy of 97% (sensitivity of 100% and specificity of 88.5%) for distinguishing UD and lymphoma. Conclusions: There are significant differences in the DCE parameters which show the potential for distinguishing UD from SCC or lymphoma. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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