4.8 Article

Asymmetric Latent Carbocation Catalysis with Chiral Trityl Phosphate

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 49, 页码 15576-15583

出版社

AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b11085

关键词

-

资金

  1. Natural Science Foundation of China [21390400, 21202170, 21472193]
  2. National Basic Research Program of China [2012CB821600]
  3. National Program of Top-notch Young Professionals
  4. CAS One-hundred Talents Program
  5. CAS Youth Innovation Promotion Association

向作者/读者索取更多资源

Stable carbocations such as tritylium ions have been widely explored as organic Lewis acid catalysts and reagents in organic synthesis. However, achieving asymmetric carbocation catalysis remains elusive ever since they were first identified over one century ago. The challenges mainly come from their limited compatibility, scarcity of chiral carbocations, as well as the extremely low barrier to racemization of chiral carbenium ions. We reported here a latent concept for asymmetric carbocation catalysis. In this strategy, chiral trityl phosphate is employed as the carbocation precursor, which undergoes facile ionic dissociation upon mild external stimulation (e.g., acid, H-bonding, polar substrates) to form a catalytically active chiral ion pair for substrate activation and chiral induction. The latent strategy provides a solution for the long sought-after asymmetric carbocation catalysis as illustrated in three different enantioselective transformations.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据