期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 32, 页码 10100-10103出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b05848
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资金
- EPSRC [EP/I038071/1]
- Bristol University
- EPSRC [EP/K03927X/1, EP/I038071/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I038071/1, EP/K03927X/1] Funding Source: researchfish
The enantiospecific conversion of chiral secondary boronic esters into alkylfluorides is reported. Boronate complexes derived from boronic esters and PhLi were used as nucleophiles, with Selectfluor II as the electrophilic fluorinating agent, to afford alkylfluorides in short reaction times. The addition of styrene as a radical trap was found to enhance enantiospecificity. A broad range Of alkyl boronic esters were converted into alkylfluorides with almost complete enantiospecificity by this method.
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