期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 5, 页码 1794-1797出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja512817f
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资金
- CSIR
- Department of Science and Technology, India
In the context of processing of molecular solids, especially pharmaceuticals, hardness is an important property that often determines the manufacturing steps employed. Through nanoindentation studies on a series of omeprazole polymorphs, in which the proportions of the 5- and 6-methoxy tautomers vary systematically, we demonstrate that solid-solution strengthening can be effectively employed to engineer the hardness of organic solids. High hardness can be attained by increasing lattice resistance to shear sliding of molecular layers during plastic deformation.
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