期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 28, 页码 8892-8895出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b04946
关键词
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资金
- NIGMS [GM80442]
- Swiss National Science Foundation
alpha,beta-Unsaturated - oxime pivalates are proposed to undergo reversible C(sp(2))-H insertion with cationic Rh (III) complexes to furnish five-membered metallacycles. In the presence of 1,1-disubstituted olefins, these species participate in irreversible migratory insertion to give, after reductive elimination, 2,3-dihydropyridine products in good yields. Catalytic hydrogenation can then be used to. convert these molecules into piperidines, which are important structural components of numerous pharmaceuticals.
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