期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 19, 页码 6112-6115出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b00795
关键词
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资金
- Northeastern University start-up
- NEU-DFCI seed grant
- NSF CAREER award [1453255]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1453255] Funding Source: National Science Foundation
The simultaneous intracellular delivery of multiple types of payloads, such as hydrophobic drugs and nucleic acids, typically requires complex carrier systems. Herein; we demonstrate a, self-deliverable form of nucleic acid-drug nanostructure that is composed almost entirely of payload molecules. Upon light activation, the nanostructure sheds the nucleic acid shell, while the core, which consists of prodrug molecules, disintegrates via an irreversible self-immolative process, releasing free drug molecules and small molecule fragments. We demonstrate that the nanostructures exhibit enhanced stability against DNase I compared with free DNA, and that the model drug (camptothecin) released exhibits similar efficacy as free, unmodified drugs toward cancer cells.
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