期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 50, 页码 15668-15671出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b11335
关键词
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资金
- National Institute of Health [R01GM063540]
- NSF [CHE-1361296]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1358740, 1361296] Funding Source: National Science Foundation
An enantioselective, intermolecular dehydrogenative Heck arylation of trisubstituted alkenes to construct remote quaternary stereocenters has been developed. Using a new chiral pyridine oxazoline ligand, good to high enantioselectivity is achieved for various combinations of indole derivatives and trisubstituted alkenes. However, some combinations of substrates led to lower enantioselectivity, which provided the impetus to use structure enantioselectivity correlations to design a better performing ligand.
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