期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 51, 页码 16024-16027出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b12131
关键词
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资金
- Robert A. Welch Foundation [F-0038]
- NIH-NIGMS [RO1-GM069445]
A chiral iridium complex formed in situ from [Ir(cod)Cl](2) and (R)-H-8-BINAP is found to catalyze the direct enantioselective C C coupling of a simple propargyl ether, TIPSOCH2C CH, with primary alcohols to form gamma-hydroxy (Z)-enol silanes with uniformly high enantioselectivity and complete alkene (Z)-stereo-selectivity. As corroborated by deuterium labeling studies, these studies represent the first examples of 1,2-hydride shift-enabled pi-allyl formation in the context of iridium catalysis.
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