期刊
ACS NANO
卷 9, 期 7, 页码 7085-7096出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b02635
关键词
renal clearance; CuS nanodots; photothermal therapy; PET imaging; toxicity
类别
资金
- National Institutes of Health [U54 CA151668, P30CA016672]
- John S. Dunn Foundation
Translation of nanoparticles (NPs) into clinical practice has been limited by toxic effects induced by nonspecific accumulation of NPs in healthy organs after systemic administration. The ideal NPs should accumulate in the target site, carry out their function, and then ultimately be eliminated from the body. Here, we show a single-compartment, multifunctional ultrasmall copper sulfide nanodot (CuS ND) that is rapidly cleared from the body. These CuS NDs have a hydrodynamic diameter of <6 nm, can efficiently absorb near-infrared light for photothermal ablation therapy, and stably incorporate the copper-64 radioisotope for noninvasive positron emission tomography (PET). Importantly, similar to 95% of CuS NDs are excreted intact through the renal urinary system within 24 h with minimal retention in the liver and the spleen. The ultrasmall CuS NDs accumulate in 4T1 tumors in Balb/c mice, as monitored by PET imaging, and mediate tumor ablation when combined with near-infrared light irradiation. As a first example of PET-visible, renal-clearable inorganic nanomaterials with peak absorption in the near-infrared region, CuS NDs represent a robust platform for cancer imaging and therapy.
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