期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 739, 期 -, 页码 83-95出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2013.11.012
关键词
Ryanodine receptor; IP3R; ER; Neuron; Brain; Neurodegeneration; Calcium; Alzheimer's disease; Synaptic plasticity; Amyloid; Clinical trials
Calcium ions are versatile and universal biological signaling factors that regulate numerous cellular processes ranging from cell fertilization, to neuronal plasticity that underlies learning and memory, to cell death. For these functions to be properly executed, calcium signaling requires precise regulation, and failure of this regulation may tip the scales from a signal for life to a signal for death. Disruptions in calcium channel function can generate complex multi-system disorders collectively referred to as calciumopathies that can target essentially any cell type or organ. In this review, we focus on the multifaceted involvement of calcium signaling in the pathophysiology of Alzheimer's disease (AD), and summarize the various therapeutic options currently available to combat this disease. Detailing the series of disappointing AD clinical trial results on cognitive outcomes, we emphasize the urgency to design alternative therapeutic strategies if synaptic and memory functions are to be preserved. One such approach is to target early calcium channelopathies centrally linked to AD pathogenesis. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据