期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 734, 期 -, 页码 83-90出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2014.04.007
关键词
Myofibroblast differentiation; Dedifferentiation; Molecular mechanisms; Mediators; Drugs
资金
- National Natural Science Foundation of China [81072685, 81272995]
- Open Project of National Key Laboratory of Respiratory Diseases of China [2007DA780154F0912]
It has long been considered that fibrosis and fibroblast-to-myofibroblast differentiation are irreversible processes. However, recent data obtained indicates that tissue fibrosis and fibroblast-to-myofibroblast differentiation can indeed be reversed, which offers the possibility of a new therapeutic approach for fibrotic disorders. Here, we discuss the origin of the myofibroblasts and different aspects of their differentiation, especially the key mediators and TGF beta-induced signaling pathways. We also report here a few factors involved in myofiroblast dedifferentiation and several compounds which can reverse the established dedifferentiated myofibroblast, as examples that provide the reader a glimpse of the current trends of approach for discovering useful anti-fibrotic drugs. (C) 2014 Elsevier B.V. All rights reserved.
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