4.8 Article

Palladium-Catalyzed Intramolecular Insertion of Alkenes into the Carbon Nitrogen Bond of β-Lactams

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 27, 页码 8708-8711

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AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b05308

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资金

  1. MEXT [22105005, 15H05756, 26620083]
  2. ACT-C Program of the JST
  3. Grants-in-Aid for Scientific Research [22105005, 26620083, 15H05756] Funding Source: KAKEN

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The carbon-nitrogen bond of beta-lactams is cleaved by palladium(0), and an alkene is intramolecularly inserted therein. The following reductive elimination produces nitrogen-containing benzo-fused tricycles in good to high yields.

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