期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 698, 期 1-3, 页码 235-245出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2012.07.038
关键词
Superior colliculus; Periaqueductal grey matter; Innate fear; Intra-tectal opioid pathway; Tecto-nigral opioid pathway; Panic-attack
资金
- CNPq [proc.483763/2010-1, proc. 142844/2011-0, proc. 301905/2010-0, proc. 501858/2005-9, proc. 372654/2006-1, proc. 372810/2008-0, proc. 372877/2010-9]
- FAEPA [proc. 70/202, 210/2005, 345/2009]
- FAPESP [proc. 1995/3604-4, 1995/8418-4, 2007/01174-1, 2009/54014-7, 2009/02458-9, proc. 2009/17258-5, TT-2, proc. 02/01497-1]
- USP Pro-Rectory [IaPq2012, NAP-USP-NuPNE-156]
- Scientific Initiation scholarship [proc. 01/03752-6]
- Magister Scientiae fellowship [proc. 03/05256-1]
- Scientiae Doctor Fellowship
- CAPES
- CNPq in the Department of Physiology, Anatomy and Genetics [200629/2005-0]
- FMRIB Centre of the Clinical Neurology Department of the University of Oxford, Oxford, England, UK
The chemical neuroanatomy and the effects of central administration of opioid antagonists on the innate fear-induced responses elicited by electrical (at escape behaviour threshold) stimulation of the midbrain tectum were determined. The aim of the present work was to investigate the interaction between the tecto-nigral endogenous opioid peptide-mediated disinhibitory pathways and nigro-tectal inhibitory links in the control of panic-like behaviour and their organisation in the continuum comprised by the deep layers of the superior colliculus (dISC) and the dorsolateral columns of the periaqueductal grey matter (dlPAG ). Beta-endorphin-labelled neurons and fibres were found in the dorsal midbrain and also in the substantia nigra. Opioid varicose fibres and terminal buttons were widely distributed in PAG columns and in all substantia nigra subdivisions. Microinjections of naltrexone (a non-selective opioid receptor antagonist; 5.0 mu g/0.2 mu l) or nor-binaltorphimine (a selective kappa-opioid receptor antagonist; 5.0 mu g/0.2 mu l) in the dlSC/dlPAG continuum, in independent groups of animals, induced significant increases in the escape thresholds for midbrain tectum electrical stimulation. The microinjection of naltrexone or nor-binaltorphimine into the SNpr also increased the escape behaviour threshold for electrical stimulation of dlSC/dlPAG . These morphological and neuropharmacological findings support previous evidence from our team for the role played by the interaction between opioidergic and GABAergic mechanisms in the modulation of innate fear-induced responses. The present data offer a neuroanatomical basis for both intratectal axo-axonic/pre-synaptic and tecto-nigral axo-somatic opioid inhibition of GABAergic nigro-tectal neurons that modulate the dorsal midbrain neurons related to the organisation of fear-related emotional responses. (c) 2012 Elsevier B.V. All rights reserved.
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