期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 43, 页码 13760-13763出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b09146
关键词
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资金
- Western-Light Foundation of CAS
- NSFC [21472184, 21572218, 21272226, 21402186]
A cooperative Cu/Pd-catalyzed asymmetric three-component reaction of styrenes, B-2(pin)(2), and allyl carbonates was reported. This reaction, in the presence of chiral CuOAc/SOP and achiral Pd(dppf)Cl-2 catalysts, occurs smoothly with high enantioselectivities (up to 97% ee). The allylboration products, which contain alkene (or diene) unite and alkylboron group, are easily functionalized. The utility of this protocol was demonstrated through the synthesis of an antipsychotic drug, (-)-predamol.
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