期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 35, 页码 11246-11249出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b07203
关键词
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资金
- NIH-NIGMS [GM098314]
A new type of Pd-catalyzed alkene carboamination reaction that provides direct access to enantioenriched 2-aminoindanes from 2-allylphenyltriflate derivatives and aliphatic amines is described. A catalyst generated in situ from Pd(OAc)(2) and (S)-tert-butylPHOX provides the functionalized carbocycles in good yield with up to >99:1 er. The transformations occur via a key anti-aminopalladation that involves intermolecular attack of an amine nudeophile on an arylpalladium alkene complex.
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