期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 658, 期 2-3, 页码 263-269出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2011.02.013
关键词
Aloperine; Atopic dermatitis; Mast cells; Eosinophil; IgE; Cytokine
资金
- Air Force General Hospital
- Xinjiang Hope Pharmaceutical Company
- Institute of Psychology of Chinese Academy of Sciences [08CX043004]
- Key Laboratory of Mental Health of Chinese Academy of Sciences
- National Natural Science Foundation of China [30800301]
- Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-J-8, KSCX2-EW-Q-18]
Aloperine has been shown to inhibit 2,4-dinitrofluorobenzene (DNFB) induced allergic contact dermatitis in BALB/c mice. In the present study, we further investigated the effect of aloperine on DNFB-induced atopic dermatitis-like skin lesions in NC/Nga mice. NC/Nga mice elicited atopic dermatitis-like skin lesions after the topical application of DNFB. Aloperine treatment significantly inhibited dermatitis index and ear thickness in DNFB-treated NC/Nga mice in a dose-dependent manner. Eosinophils, mast cells infiltration into the ears and plasma level of immunoglobulin (Ig) E were also suppressed by aloperine treatment. Finally, cytokine (interleukin (IL)-1 beta, IL-4, IL-6, IL-10, IL-13, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma) productions in ear biopsies homogenates were significantly elevated after DNFB challenge. Topical application of aloperine increased the immunosuppressive cytokine IL-10 level, while it reduced other cytokines production in a dose-dependent manner. Taken together, these data suggest that aloperine may be one of the effective therapeutic agents for the treatment of atopic dermatitis. (C) 2011 Elsevier B.V. All rights reserved.
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