期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 46, 页码 14594-14597出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b10310
关键词
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资金
- National Natural Science Foundation of China [21421091, 21432011, 21272250]
- National Basic Research Program of China [2015CB856600]
- Chinese Academy of Sciences
The first catalytic enantioselective ring-opening reaction of donoracceptor cyclopropanes with water is described. By employing Cy-TOX/Cu(II) as catalyst, the reaction performed very well over a broad range of substrates, leading to the ring-opening products in 7096% yields with up to 95% ee under mild conditions. The current method provides a new approach to direct access to gamma-substituted GBH derivatives very efficiently. Importantly, Cu(ClO4)(2)center dot 6H(2)O proves to serve as both a Lewis acid and a source of water, which affords a fine system to controllably release water as a nucleophile in the asymmetric catalysis.
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