期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 24, 页码 7869-7880出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b03925
关键词
-
资金
- Natural Science Foundation of China [21476165, 51173128, 21306134]
- 863 Program of China [2013AA102204]
- Ministry of Science and Technology of China [2012YQ090194]
- Ministry of Education [20130032120029]
- Tianjin University
- Program of Introducing Talents of Discipline to Universities of China [B06006]
We report a new paradigm for the rational design of chiral nanostructures that is based on the hierarchical self-assembly of a ferrocene (Fc)-modified dipeptide, ferrocene-l-Phe-l-Phe-OH (Fc-FF). Compared to other chiral self-assembling systems, Fc-FF is unique because of its smaller size, biocompatibility, multiple functions (a redox center), and environmental responsiveness. X-ray and spectroscopic analyses showed that the incorporation of counterions during the hierarchical self-assembly of Fc-FF changed the conformations of the secondary structures from flat beta sheets into twisted beta sheets. This approach enables chiral self-assembly and the formation of well-defined chiral nanostructures composed of helical twisted beta sheets. We identified two elementary forms for the helical twist of the beta sheets, which allowed us to create a rich variety of rigid chiral nanostructures over a wide range of scales. Furthermore, through subtle modulations in the counterions, temperature, and solvent, we are able to precisely control the helical pitch, diameter, and handedness of the self-assembled chiral nanostructures. This unprecedented level of control not only offers insights into how rationally designed chiral nanostructures can be formed from simple molecular building blocks but also is of significant practical value for the use in chiroptics, templates, chiral sensing, and separations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据