期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 616, 期 1-3, 页码 244-250出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2009.06.039
关键词
Heart-type fatty acid-binding protein; Leptin; Multiple organ dysfunction syndrome; Radioimmunoassay; Sepsis; Recovery of function
资金
- National Natural Science Foundation of China [30670821]
- Nursery Fund of Chinese PLA General Hospital [06MP83]
Heart-type fatty acid-binding protein (H-FABP) is widely distributed and has been used to diagnose certain diseases. However, its alteration during infection-evoked organ dysfunction, and the potential association between leptin and it in injury or infection has not been investigated. In the current study, serum H-FABP, leptin, C-reactive protein and interleukin-1 beta in the patients with pulmonary infection-induced multiple organ dysfunction were detected. Moreover, a mouse model of sepsis was established, and serum alanine transaminase, uric acid, tissue H-FABP, myeloperoxidase, superoxide dismutase activity and histological alterations in lung and intestine were investigated. Serum H-FABP and leptin increased simultaneously and significantly in the patients, and leptin alleviated pulmonary and intestinal injuries by restraining tissue H-FABP secretions in the mouse model of sepsis. Other investigated variables showed different but independent alterations. In conclusion, H-FABP represents a useful diagnostic marker for organ dysfunction, and its association with leptin will be a novel target for emergency aid. (C) 2009 Elsevier B.V. All rights reserved.
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