期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 591, 期 1-3, 页码 252-258出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2008.06.065
关键词
MDR; Curcuma longa; apoptosis; MAPK; P-glycoprotein; Calebin-A
资金
- National Natural Science Foundation of China [30170465, 30228012]
- Military Research Foundation of China [06G092]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0459]
This study is the first to investigate Calebin-A, a natural compound present in Curcuma longa, which inhibits cell growth and induce apoptosis in SGC7901/VINCRISTINE cells, a multidrug resistant (MDR) human gastric adenocarcinoma cell line. Our data suggest the drug efflux function of P-glycoprotein was inhibited by Calebin-A treatment, while the expression level of P-glycoprotein was not affected. Additionally, co-treatment of Calebin-A and vincristine resulted in a remarkable reduction in S phase and G2/M phase arrest in SGC7901/VINCRISTINE cells. Calebin-A was also found to modulate the activities of mitogen-activated protein kinase (MAPK) family members, which includes decreased c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and increased protein kinase of 38 kDa (p38) activity. These results suggest that Calebin-A might be an effective compound for the treatment of human gastric and other MDR cancers. (C) 2008 Elsevier B.V. All rights reserved.
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