期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 583, 期 2-3, 页码 255-262出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2007.11.073
关键词
glucocorticoid receptor; mineralocorticoid receptor; proteasome; ultradian rhythm
资金
- Biotechnology and Biological Sciences Research Council [BB/C51297X/1] Funding Source: Medline
- Wellcome Trust [074112] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/C51297X/1] Funding Source: researchfish
Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately hourly rhythm of corticosterone secretion, which appears to be regulated by alternating activation and inhibition of the HPA axis. At the level of signal transduction, the response to these pulses of corticosterone is determined by its dynamic interaction with the two transcription factors - the glucocorticoid and mineralocorticoid receptors. While the mineralocorticoid receptor remains activated throughout the ultradian cycle, the glucocorticoid receptor shows a phasic response to each individual pulse of corticosterone. This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据