期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 584, 期 2-3, 页码 357-360出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2008.02.023
关键词
corticotropin releasing factor; corticotropin releasing hormone; contextual fear conditioning; elevated plus maze; median raphe nucleus; fear memory
In the present study, we examined the role of corticotropin releasing factor (CRF) in the median raphe nucleus (MRN) on fear-related behaviors in rats. We employed the contextual fear conditioning test and the elevated plus maze test as memory-dependent and -independent tasks, respectively. Human/rat CRF (10 ng) in 0.5 mu l saline was injected into the MRN. Administration of CRF significantly increased memory dependent, but not independent, fear expression. These results suggest that CRF release in the MRN is involved in the retrieval of fear memory. (c) 2008 Elsevier B.V All rights reserved.
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