期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 583, 期 1, 页码 108-114出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2008.01.003
关键词
histamine; pyrilamine; ranitidine; anxiety; elevated plus-maze; (Rat)
The central histaminergic system is known to have modulatory influence on anxiety-related behaviour both in animals and humans through histamine H-1 and/or H-2 receptors. In the present study, the effects of intra-lateral septal microinjections of histaminergic agents on anxiety-related behaviours in male Wistar rats have been investigated. As a model of anxiety, the elevated plus-maze which is a useful test to investigate the effects of anxiogenic or anxiolytic drugs in rodents was used. Intra-lateral septal administration of histamine (0.5 and 1 mu g/rat) decreased the percentage of open arm entries and open arm time but not locomotor activity, showing an anxiogenic response. The intra-lateral septal injections of different doses of the histamine H1 receptor antagonist, pyrilamine (5, 10 and 20 mu g/rat) or the histamine H2 receptor antagonist, ranitidine (5, 10 and 20 mu g/rat) could not significantly alter the anxiety-like parameters in the plus-maze test. However, intra-lateral septal injections of different doses of pyrilamine (10 and 20 mu g/rat) or ranitidine (10 and 20 mu g/rat) significantly reversed histamine (1 mu g/rat)-induced anxiogenic effect. The results may indicate that the histaminergic system of lateral septum modulate anxiety-like behaviour through histamine H1 and H2 receptors. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据