期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 596, 期 1-3, 页码 98-101出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2008.08.012
关键词
Cannabinoid receptors; 5-HT3 receptor; Anandamide; Delta(9)-tetrahydrocannabinol
资金
- Federal Ministry of Education and Research [NGFN2]
- German Research Foundation [DFG, FOR 926]
Studies in knockout mouse strains have shown that some cannabimimetic effects persist in animals lacking cannabinoid CB1 and CB2 receptors. These residual effects are thought to result, in part, from a cannabinoid-modulation of ion channels. This study investigates the role of 5-HT3 receptors as a potential in vivo target for cannabinoids. Mice deficient in CB1 and CB2 receptors were treated with Delta(9)-tetrahydrocannabinol and anandamide, in the presence of the 5-HT3 antagonist ondansetron. We show that the cannabinoid receptor-independent anandamide analgesia, but not catalepsy, is completely blocked by ondansetron. Thus, 5-HT3 receptors seem to be involved in cannabinoid analgesia. (C) 2008 Elsevier B.V. All rights reserved.
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