期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 88, 期 1, 页码 8-27出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2014.03.004
关键词
Intranasal delivery; Nasal route; Systemic-acting drugs; Pharmacokinetics; Small-molecule drugs; Biomacromolecule
资金
- Fundacao para a Ciencia e Tecnologia (Portugal) [SFRH/BD/64895/2009, SFRH/BD/69378/2010]
- POPH (Programa Operacional Potencial Humano)
- FSE (Fundo Social Europeu), Uniao Europeia
- Fundação para a Ciência e a Tecnologia [SFRH/BD/69378/2010, SFRH/BD/64895/2009] Funding Source: FCT
As a non-invasive route, intranasal administration offers patient comfort and compliance which are hurdled in parenteral drug therapy. In addition, the current recognition that the high permeability and vascularization of nasal mucosa coupled to the avoidance of the first-pass elimination and/or gastrointestinal decomposition ensure higher systemic drug absorption than oral route has contributed to the growing interest for intranasal delivery of drugs that require considerable systemic exposure to exert their therapeutic actions (systemic-acting drugs). Nevertheless, several features may hamper drug absorption through the nasal mucosa, particularly the drug molecular weight and intrinsic permeability, and, therefore, several strategies have been employed to improve it, propelling a constant challenge during nasal drug (formulation) development. This review will firstly provide an anatomical, histological and mechanistic overview of drug systemic absorption after nasal administration and the relevant aspects of the therapeutic interest and limitations of the intranasal systemic delivery. The current studies regarding the nasal application of systemic-acting small drugs (analgesic drugs, cardiovascular drugs and antiviral drugs) and biomacromolecular drugs (peptide/protein drugs and vaccines) will also be outlined, addressing drug pharmacokinetics and pharmacodynamic improvements. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据