期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 76, 期 2, 页码 282-289出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2010.07.001
关键词
Microneedle; Fabrication; Polymer film; Drug delivery property; Mechanical property
资金
- US National Institutes of Health
- Ministry of Education, Science and Technology [2009-0072054]
- GRRC program of Gyeonggi province [GRRC Kyungwon 2009-B03]
- Kyungwon University
- National Research Foundation of Korea [2009-0072054] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Microneedle rollers have been used to treat large areas of skin for cosmetic purposes and to increase skin permeability for drug delivery. In this study, we introduce a polymer microneedle roller fabricated by inclined rotational UV lithography, replicated by micromolding hydrophobic polylactic acid and hydrophilic carboxy-methyl-cellulose. These microneedles created micron-scale holes in human and porcine cadaver skin that permitted entry of acetylsalicylic acid. Trypan blue and nanoparticles measuring 50 nm and 200 nm in diameter. The amount of acetylsalicylic acid delivered increased with the number of holes made in the skin and was 1-2 orders of magnitude greater than in untreated skin. Lateral diffusion in the skin between holes made by microneedles followed expected diffusional kinetics, with effective diffusivity values that were 23-160 times smaller than in water. Compared to inserting microneedles on a flat patch, the sequential insertion of microneedles row by row on a roller required less insertion force in full-thickness porcine skin. Overall, polymer microneedle rollers, prepared from replicated polymer films, offer a simple way to increase skin permeability for drug delivery. (C) 2010 Elsevier B.V. All rights reserved.
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