期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 73, 期 2, 页码 205-218出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2009.06.009
关键词
Intra-articular; Drug delivery; Osteoarthritis; Rheumatoid arthritis; Liposomes; Nanoparticles; Microparticles; Depot formulation; Review
Osteoarthritis and rheumatoid arthritis are rheumatic diseases for which a curative treatment does not currently exist. Their management is directed towards pain relief achieved with different classes of drugs among which non-steroidal and steroidal anti-inflammatory substances are the most frequently used agents. Nevertheless, the oral or systemic administration of such drugs is hindered by numerous side effects, which could be overcome by their intra-articular (i-a.) administration as dosage forms capable of gradually releasing the active substance. The present review article summarises the research done in the field of drug delivery systems for i-a. injection vs. current management of osteoarthritis or rheumatoid arthritis. Aspects such as the influence of size, shape, polymer matrix or targeted drug on the i-a. retention time, phagocytosis and biological activity will be discussed. Finally, we will comment on the need for adapted delivery systems for the novel and very potent anti-inflammatory drugs, such as inhibitors of the p38 mitogen-activated protein kinase or the IL-1 beta conversion enzyme, which to date cannot be properly used due to the severe side effects associated with their systemic administration. (C) 2009 Elsevier B.V. All rights reserved.
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