期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 71, 期 1, 页码 2-22出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2008.08.012
关键词
Solid dosage form; Tomography; Non-destructive testing; Process analytical technology (PAT); Controlled release; X-ray microtomography; Magnetic resonance imaging (MRI); NMR imaging; NMR microscopy; Terahertz pulsed imaging (TPI); Optical coherence tomography (OCT)
资金
- RCUK Basic Technology Programme
Tomographic imaging techniques offer new prospects for a better understanding of the quality, performance and release mechanisms of pharmaceutical solid dosage forms. It is only over the last fifteen years that tomography has been applied for the in-vitro characterisation of dosage forms. This review aims to introduce the concept of tomography in a pharmaceutical context, and describes the current state-of-theart of the four most promising techniques: X-ray computed microtomography, magnetic resonance imaging, terahertz imaging and optical coherence tomography. The basic working principles of the techniques are introduced and the current pharmaceutical applications of the technologies are discussed, together with a comparison of their specific strengths and weaknesses. Possible future developments in these fields are also discussed. (c) 2008 Elsevier B.V. All rights reserved.
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